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Gene Mapping

Genes are just patterns of chemical molecules that are held within the replicating DNA mechanism.  The way they are encoded onto DNA can be likened to any other mechanism for copying and recording data: a DVD or even a vinyl record or the memory in this computer.  As a result they can be altered or damaged from time to time and some of these variations are successfully copied into subsequent offspring.  If they are particularly advantageous to survival and reproduction these changes, or mutations, rapidly spread throughout the species, so that over tens of thousands of years, individuals successful in one environmental niche are so different from those successful in another that a new species has formed (followed by a new genus, family, order, and so on). 

This process of periodic differentiation has been likened to the branching of a tree but because of the activity of bacteria and viruses and residual DNA that may be reactivated as well as limited cross-species reproduction  (for example later Humans and Neanderthal) it is no longer believed to be quite that simple.

DNA encodes the instructions for creating each cellular colony, defining each species, and each individual within a species. DNA changes over time in such away that each change is a development on previous generations. So it is possible to trace DNA ancestry back through generations of a particular species over time.  For example, DNA studies are increasingly shedding light on the questions around human origins. 

Most animals, including humans, carry two types of DNA.  Our main genome is carried by the chromosomes in the nucleus of each of our cells. This comes from both our parents. The secondary genome, mtDNA, is carried by bacteria-like organelles within each of our cells, that convert sugars for cell energy, called mitochondria. These are all cloned (reproduced by asexual division) from the mitochondria that were within the original egg cell provided by our mother.

Cells may contain from one mitochondrion to several thousand mitochondria depending on species and cell differentiation.  As a result this is the predominant DNA found in a cellular sample.

So our mtDNA comes only from our mother; in turn from her mother; and so on and mtDNA allows us to map the female ancestral line.  This original egg cell was fertilised by a sperm from our father (sperm do not contribute their mitochondria). Once fertilised, the egg cell then divided repeatedly, differentiating in accordance with the coding instructions in our DNA, into the many cells that form the cellular colony that became 'us'.

Males are differentiated from females by a Y chromosome in place of one X. So sons can only inherit this from their father (like their family name in our culture) and periodic mutations in the DNA of the Y chromosome allow the (actual) male ancestral line to be traced back.

As a result of this work we now know that humans on the planet are all descended from a single group that left Africa less than 70 thousand years ago. 

Recent DNA analysis shows that early humans sometimes interbred with the Neanderthal; a separate hominid subspecies that left Africa much earlier and settled in the Middle East and Europe over quarter of a million years ago.

It's amazing to think that we have only understood it within my lifetime. Now the ancient view that people grow from a seed, provided by their father, and gain the spark of life at 'conception' from a god is totally debunked. So throw away all those ancient texts.

 

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Travel

South Korea & China

March 2016

 

 

South Korea

 

 

I hadn't written up our trip to South Korea (in March 2016) but Google Pictures gratuitously put an album together from my Cloud library so I was motivated to add a few words and put it up on my Website.  Normally I would use selected images to illustrate observations about a place visited.  This is the other way about, with a lot of images that I may not have otherwise chosen.  It requires you to go to the link below if you want to see pictures. You may find some of the images interesting and want to by-pass others quickly. Your choice. In addition to the album, Google generated a short movie in an 8mm style - complete with dust flecks. You can see this by clicking the last frame, at the bottom of the album.

A few days in Seoul were followed by travels around the country, helpfully illustrated in the album by Google generated maps: a picture is worth a thousand words; ending back in Seoul before spending a few days in China on the way home to OZ. 

Read more: South Korea & China

Fiction, Recollections & News

Peter Storey McKie

 

 

My brother, Peter, is dead. 

One of his body's cells turned rogue and multiplied, bypassing his body's defences. The tumour grew and began to spread to other organs.  Radiation stabilised the tumour's growth but by then he was too weak for chemo-therapy, which might have stemmed the spreading cells.

He was 'made comfortable' thanks to a poppy grown in Tasmania, and thus his unique intelligence faded away when his brain ceased to function on Sunday, 22nd May 2022.

I visited him in the hospital before he died.  Over the past decade we had seldom spoken. Yet he now told me that he often visited my website. I had suspected this because from time to time he would send e-mail messages, critical of things I had said. That was about the only way we kept in touch since the death of his daughter Kate (Catherine). That poppy again.  

Read more: Peter Storey McKie

Opinions and Philosophy

The race for a SARS-CoV-2 vaccine

 

 

 

 

As we all now know (unless we've been living under a rock) the only way of defeating a pandemic is to achieve 'herd immunity' for the community at large; while strictly quarantining the most vulnerable.

Herd immunity can be achieved by most people in a community catching a virus and suffering the consequences or by vaccination.

It's over two centuries since Edward Jenner used cowpox to 'vaccinate' (from 'vacca' - Latin for cow) against smallpox. Since then medical science has been developing ways to pre-warn our immune systems of potentially harmful viruses using 'vaccines'.

In the last fifty years herd immunity has successfully been achieved against many viruses using vaccination and the race is on to achieve the same against SARS-CoV-2 (Covid-19).

Developing; manufacturing; and distributing a vaccine is at the leading edge of our scientific capabilities and knowledge and is a highly skilled; technologically advanced; and expensive undertaking. Yet the rewards are potentially great, when the economic and societal consequences of the current pandemic are dire and governments around the world are desperate for a solution. 

So elite researchers on every continent have joined the race with 51 vaccines now in clinical trials on humans and at least 75 in preclinical trials on animals.

Read more: The race for a SARS-CoV-2 vaccine

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